Adrian Teo Laboratory

Publications

PUBLICATIONS AS A FIRST OR CORRESPONDING AUTHOR

Chen, J.T.#, Dadheech, N.#, Tan, H.P.E.#, Ng, H.J.N., Koh, B.C.M., Shapiro, J.*, and Teo, K.K.A.* (2025) Stem cell therapies for diabetes. Nat Med, accepted.

Kong, D.W.#, Kowalik, O.#, Garratt, E., Godfrey, K.M., Chan, S.-Y., and Teo, K.K.A. (2025). Genetics and epigenetics in gestational diabetes contributing to type 2 diabetes. Trends Endo Metab, accepted.
#First authors

Tan, W.X., Lim, Y.X.L., Afsha, N., Chan, M.E.G., Ching, C., Oguz, G., Neo, S.P., Ali, M.S., Ramasamy, A., Gunaratne, J., Hunziker, W., Khoo, C.M., and Teo, K.K.A. (2025). ZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion. PNAS Nexus, accepted.

Tan, L.S., Lau, H.H., Abdelalim, E., Khoo, C.M., O’Brien, R.M., Tai, E.S., and Teo, K.K.A. (2025). The role of glucose-6-phosphatase activity in glucose homeostasis and its potential for diabetes therapy. Trends Mol Med, accepted.

Ng, H.J.N., Ghosh, S., Bok, C.M., Ching, C., Low, S.J.B., Chen, J.T., Lim, X.H.E., Miserendino, M.C., Tan, Y.S., Hoon, S., and Teo, K.K.A. (2024). HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes. Nat Comms, accepted.

Lau, H.H.#, Krentz, A.J.N.#, Abaitua, F., Perez-Alcantara, M., Chan, J.W., Ajeian, J., Ghosh, S., Lee, Y., Yang, J., Thaman, S., Champon, B., Sun, H., Jha, A., Hoon, S., Tan, N.S., Gardner, D., Kao, S.L., Tai, E.S., Gloyn, L.A.*, and Teo, K.K.A.* (2023). PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development. Nat Comms, accepted. #First authors *Corresponding authors

Lau, H.H., Amirruddin, N.S., Loo, S.W.L., Chan, J.W., Iich, E., Krishnan, V.G., Hoon, S., and Teo, K.K.A. (2023). FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro. iScience, accepted.

Chan, J.W.#, Neo, W.Y.C.#, Ghosh, S., Choi, H.W., Lim, S.C., Tai, E.S., and Teo, K.K.A. (2023). HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells. Cell Death Disease 14(5), 302. May 3 #First authors

Tan, W.X., Sim, X.L., Khoo, C.M., and Teo, K.K.A. (2023). Prioritization of type 2 diabetes-associated genes for functional studies. Nat Rev Endocrinol., accepted. May 11

Seow, W.Q.#, Lim, Y.X.L.#, Kong, D.W., and Teo, K.K.A. (2023). Stem cell epigenetics in development and disease. Epigenetics in Human Disease, Third Edition, Volume 1. #First authors

Lim, Y.X.L., Ding, S.L.S., Muthukumaran, P., Teoh, S.H., Koh, Y.X., and Teo, K.K.A. (2023). Tissue engineering of decellularized pancreas scaffolds for regenerative medicine in diabetes. Acta Biomaterialia 157, 49-66. Feb

Tan, W.X., Bok, C.M., Ng, H.J.N., and Teo, K.K.A. (2022). Chromatin immunoprecipitation in human pluripotent stem cell-derived 3D organoids to analyze DNA-protein interactions. Methods Mol Biol., Volume 2429, Chapter 14, 215-232.
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Kong, D.W., Yu, H.J., Sim, X.L., White, K., Tai, E.S., Wenk, M., and Teo, K.K.A. (2022). Multidisciplinary effort to drive precision medicine for the future. Frontiers Digital Health 4, 845405. May 2

Tan, L.S.#, Chen, J.T.#, Lim, Y.X.L., and Teo, K.K.A. (2022). Manufacturing clinical-grade human induced pluripotent stem cell-derived beta cells for diabetes treatment. Cell Proliferation 55(8), e13232. Apr 26 #First authors

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Lim, Y.X.L., Ching, C.#, Kong, D.W.#, Chan, S.Y., and Teo, K.K.A. (2022). Generating pancreatic beta-like cells from human pluripotent stem cells. Methods in Cell Biology 170, 127-146. Apr 12

#Co-authors

Lau, H.H.#, Gan, S.U.#, Lickert, H., Shapiro, J.A., Lee, K.O., and Teo, K.K.A. (2021). Charting the next century of insulin replacement with cell and gene therapies. Med 2, 1138-1162. Oct 8 #First authors

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Soetedjo, A.A.P.#, Lee, J.M.#, Lau, H.H.#, Goh, G.L., An, J., Koh, Y.X., Yeong, W.Y., and Teo, K.K.A. (2021) Tissue engineering and 3D printing of bioartificial pancreas for diabetes. Trends Endo Metab 32(8), 609-622. Jun 18 #First authors

Nguyen, L., Lim, Y.X.L, Ding, S.L.S., Amirruddin, N.S., Hoon, S., Chan, S.-Y., and Teo, K.K.A. (2021). Metformin perturbs pancreatic differentiation from human embryonic stem cells. Diabetes 70, 1-14. May 6
Featured in https://research.a-star.edu.sg/articles/highlights/a-closer-look-at-metformin-in-maternal-diabetes/

Amirruddin, N.S., Tan, W.X., Tan, Y.S., Gardner, D., Bee, Y.M., Verma, C.S., Hoon, S., Lee, K.O., and Teo, K.K.A. (2021). Progressive endoplasmic reticulum stress over time due to human insulin gene mutation contributes to pancreatic β-cell dysfunction. Diabetologia 64(11), 2534-2549. Aug 27

Low, S.J.B., Lim, C.S., Tan, Y.S., Ding, S.L.S., Ng, H.J.N., Krishnan, V.G., Ang, S.F., Neo, W.Y.C., Verma, C.S., Hoon, S., Lim, S.C., Tai, E.S., and Teo, K.K.A. (2021). Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells. Nat Comms 12, 3133. May 25

Featured in https://research.a-star.edu.sg/articles/highlights/opening-the-cellular-gates-to-glucose/

Ng, H.J.N., Neo, W.Y.C, Ding, S.L.S., and Teo, K.K.A. (2021). Insights from single cell studies of human pancreatic islets and stem cell-derived islet cells to guide functional beta cell maturation in vitro. Vitamins and Hormones, Volume 116, 193-233. Mar 10

Tan, L.S., Chew, S.E.R., Ng, H.J.N., and Teo, K.K.A. (2021). Protocol for the generation of pancreatic and hepatic progenitors from human pluripotent stem cells for gene regulatory assays. STAR Protocols 2(2), 100471. Apr 19

Teo, K.K.A.*, Nguyen, L.#, Gupta, M.K.#, Lau, H.H.#, Loo, S.W.L., Jackson, N., Lim, C.S., Mallard, W., Gritsenko, M.A., Rinn, J., Smith, R.D., Qian, W.-J., and Kulkarni, R.N.* (2021). Defective insulin receptor signaling in hPSCs skews pluripotency and negatively perturbs neural differentiation. J Biol Chem. 296, 100495. Mar 3 *Corresponding authors

Tan, W.X.#, Lau, H.H.#, Tan, N.S., Khoo, C.M., and Teo, K.K.A. (2021). Considerations in using human pluripotent stem cell-derived pancreatic beta cells to treat type 1 diabetes. Recent Advances in iPSCs for Therapy, Volume 3, 173-197.

#First authors

Chan, J.W., and Teo, K.K.A. (2020). Replicates in stem cell models – how complicated! Stem Cells 38, 1055-1059. Jun 10

Loo, S.W.L., Soetedjo, A.A.P., Lau, H.H., Ng, H.J.N., Ghosh, S., Nguyen, L., Krishnan, V.G., Choi, H., Roca, X., Hoon, S., and Teo, K.K.A. (2020). BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells. Cell Death Disease 11, 378. May 18

Neo, W.Y.C.#, Ciaramicoli, L.M.#, Soetedjo, A.A.P., Teo, K.K.A.*, and Kang, N.-Y.* (2020). A new perspective of probe development for imaging pancreatic beta cell in vivo. Semin Cell Dev Biol 103, 3-13. Feb 11 #First authors *Corresponding authors

Loo, S.W.L., Vethe, H., Soetedjo, A.A.P., Paulo, J.A., Jasmen, J., Jackson, N., Bjorlykke, Y., Valdez, I.A., Vaudel, M., Barsnes, H., Gygi, S.P., Raeder, H.#, Teo, K.K.A.#*, and Kulkarni, R.N.#* (2019). Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors. Stem Cells 38, 542-555. Jan 22 #Co-senior authors *Corresponding authors

Amirruddin, N.S.#, Low, S.J.B.#, Lee, K.O., Tai, E.S.*, and Teo, K.K.A.* (2019). New insights into human beta cell biology using human pluripotent stem cells. Semin Cell Dev Biol 103, 31-40. Nov 19 #First authors *Corresponding authors

Ng, H.J.N., Tan, W.X., Koh, Y.X., and Teo, K.K.A. (2019). Human islet isolation and distribution efforts for clinical and basic research. OBM transplantation 3, 1-31.

Edited by Tatsuya Kin, M.D. Ph.D.

Ng, H.J.N.#, Jasmen, B.J.#, Lim, C.S., Lau, H.H., Krishnan, V.G., Kadiwala, J., Kulkarni, R.N., Raeder, H., Vallier, L., Hoon, S., and Teo, K.K.A. (2019). HNF4A haploinsufficiency in MODY1 abrogates liver and pancreas differentiation from patient-derived iPSCs. iScience 16, 192-205. May 27 #First authors

Featured in https://research.a-star.edu.sg/articles/highlights/getting-to-the-roots-of-early-onset-diabetes/

Kang, N.-Y.#*, Soetedjo, A.A.P.#, Amirruddin, N.S., Chang, Y.-T., Eriksson, O., and Teo, K.K.A.* (2019). Tools for bioimaging pancreatic beta cells in diabetes. Trends Mol Med 25, 708-722. Jun 6 #First authors *Corresponding authors

Featured Article

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Nguyen, L., Chan, S.Y., and Teo, K.K.A. (2018). Metformin from mother to unborn child – are there unwarranted effects? EBioMedicine 35, 394-404. Aug 27

Ng, H.J.N., and Teo, K.K.A. (2018). Heterogeneity and cell fate flux in single human pancreatic islet cells. Cell Death Disease 9, 222. Feb 14

Teo, K.K.A.*, Lim, C.S., Cheow, L.F., Kin, T., Shapiro, J.A., Kang, N.-Y., Burkholder, W., and Lau, H.H. (2018). Single cell analyses of human islet cells reveal de-differentiation signatures. Cell Death Discovery 4, 14. Feb 9 *Corresponding author

Lau, H.H., Ng, H.J.N., Loo, S.W.L., Jasmen, B.J., and Teo, K.K.A. (2018). The molecular functions of hepatocyte nuclear factors – in and beyond the liver. J Hepatol. 68, 1033-1048. May

Loo, S.W.L., Lau, H.H., Jasmen, B.J., Lim, C.S., and Teo, K.K.A. (2018). An arduous journey from human pluripotent stem cells to functional pancreatic β-cells. Diabetes, Obesity and Metabolism 20, 3-13. Jan

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Valdez, I.A., Dirice, E., Gupta, M.K., Shirakawa, J., Teo, K.K.A.*, and Kulkarni, R.N.* (2016) Proinflammatory cytokines induce endocrine differentiation in pancreatic ductal cells via STAT3-dependent NGN3 activation. Cell Reports 15, 1-11. Apr 7 *Co-senior and Co-corresponding authors
F1000Prime article recommendation: http://f1000.com/prime/726281818

Teo, K.K.A.*, Lau, H.H., Valdez, I.A., Dirice, E., Tjora, E., Raeder, H., and Kulkarni, R.N.* (2016). Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia. Stem Cell Reports 6, 357-367. Feb 11 *Corresponding authors

Featured in https://research.a-star.edu.sg/articles/highlights/gene-mutation-halts-embryonic-pancreas-

development/

Santosa, M., Low S.J.B., Pek M.Q.N., and Teo, K.K.A. (2016). Knowledge gaps in rodent pancreas biology: taking human pluripotent stem cell-derived pancreatic beta cells into our own hands. Front. Endocrinol. 6, 194. Jan 14

PUBLICATIONS AS A CONTRIBUTING AUTHOR

Aqel, Y.A., Alnesf, A., Aigha, I.I., Islam, Z., Kolatkar, P.R., Teo, K.K.A., and Abdelalim, E.M. (2024) Glucokinase (GCK) in diabetes: From molecular mechanisms to disease pathogenesis. Cellular and Molecular Biology Letters, accepted.Aqel, Y.A., Alnesf, A., Aigha, I.I., Islam, Z., Kolatkar, P.R., Teo, K.K.A., and Abdelalim, E.M. (2024) Glucokinase (GCK) in diabetes: From molecular mechanisms to disease pathogenesis. Cellular and Molecular Biology Letters, accepted.

Leow, M.K.D.#, Ng, Y.K.#, Wang, L.C., Koh, W.L.H., Zhao, T., Tabaglio, T., Narayanan, G., Giadone, R.M., Sobota, R.M., Ng, S.Y., Teo, K.K.A., Parson, S.H., Rubin, L.L., Ong, W.-Y., Darras, B.T., and Yeo, J.J.C. (2024). Liver steatosis and mitochondrial dysfunction in spinal muscular atrophy is survival motor neuron-dependent and hepatocyte-intrinsic. J Clin Invest., accepted.

#First authors

Pamies, D., Ekert, J., Zurich, M.-G., Frey, O., Werner, S., Piergiovanni, M., Freedman, B.S., Teo, K.K.A., Erfurth, H., Reyes, D.R., Loskill, P., Candarlioglu, P., Suter-Dick, L., Wang, S., Hartung, T., Coecke, S., Stacey, G., Wagegg, B.A., Dehne, E.-M., Pistollato, F., and Leist, M. (2024). Recommendations on fit-for-purpose criteria to establish quality management for Microphysiological Systems (MPS) and for monitoring of their reproducibility. Stem Cell Reports, accepted.

Ho, X.B., Teo, K.K.A., and Ng, H.J.N. (2024). Innovations in bio-engineering and cell-based approaches to address immunological challenges in islet transplantation. Frontiers in Immunology, in press.

Auto, M.I., Motakis, E., Perrin, A., Bin Amin, T., Tiang, Z., Do, D.V., Wang, J., Tan, K.M.J., Ding, S.L.S., Tan, W.X., Lee, C.J.M., Teo, K.K.A., and Foo, R. (2024). Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells. eLife 13, e79592. Jan 2

Tay, K.Y., Wu, K.-X., Chioh, F., Autio, M., Pek, M.Q.N., Narmada, C., Tan, S.-H., Low, A., Lian, M., Chew, E., Lau, H.H., Kao, S.L., Teo, K.K.A., Foo, J.N., Foo, R., Heng, C.K., Chan, M., and Cheung, C. (2022). Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease. Atherosclerosis 362, 11-22. Oct 22

Pistollato, F., Bal-Price, A., Coecke, S., Parvatam, S., Pamies, D., Czysz, K., Hao, J., Kee, K., Teo, K.K.A., Niu, S., Wilmes, A., Smirnova, L., Freund, C., Mummery, C., and Stacey, C. (2022). Quality criteria for in vitro human pluripotent stem cell-derived models of tissue-based cells. Reproductive Toxicology 112, 36-50. Jun 11

Li, J., Togashi, Y., Inoue, R., Okuyama, T., Kyohara, M., Miyashita, D., Kin, T., Shapiro, A.M., Chew, S.E.R., Teo, K.K.A., Terauchi, Y., and Shirakawa, J. (2021). Imeglimin ameliorates β-cell apoptosis by modulating the endoplasmic reticulum homeostasis pathway. Diabetes 71(3), 424-439. Mar 1

So, W.Y., Liu, W.N., Teo, K.K.A., Rutter, G.A., and Han, W. (2021). Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis. Sci Transl Med, 13(600), eabb1038. Jun 30

Tan, E.E.K., Hopkins, R., Lim, C.K., Jamuar, S., Ong, C., Thoon, K.C., Koh, M.J.A., Shin, E.M., Quan, D., Weerasooriya, M., Lee, C.Z.W., Soetedjo, A.A.P., Lim, C.S., Au, B., Chua, E., Lee, H.Y., Jones, L.A., James, S.J., Kaliaperumal, N., Kwok, J., Fouze, S., Tan, E.S., Thomas, B., Wu, L., Fairhurst, A.-M., Ginhoux, F., Teo, K.K.A., Zhang, Y., Ong, K.H., Yu, W., Venkatesh, B., Tergaonkar, V., Reversade, B., Chin, K.-C., Tan, A.M., Liew, W.K., and Connolly, J. (2020). Dominant-negative NFKBIA mutation promotes IL-1β production causing hepatic disease with severe immunodeficiency. J Clin Invest. 130(11), 5817-5832. Nov 2

Carrat, G.R., Haythorne, E., Haataja, L., Muller, A., Arvan, P., Tomas, A., Piunti, A., Cheng, K., Huang, M., Pullen, T.J., Georgiadou, E., Stylianides, T., Amirruddin, N.S., Salem, V., Distaso, W., Cakebread, A., Heesom, K.J., Lewis, P., Hodson, D.J., Linford, J.B., Fung, A., Sessions, R.B., Alpy, F., Kong, A., Benke, P., Torta, F., Teo, K.K.A., Leclerc, I., Solimena, M., Wigley, D.B., and Rutter, G.A. (2020). The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis. Mol Metab 40, 101015. May 13

Kang, N.-Y., Lee, J.Y., Lee, S.H., Song, I.H., Hwang, Y.H., Kim, M.J., Phue, W.H., Agrawalla, B.K., Wan, S.Y.D., Lalic, J., Park, S.-J., Kim, J.-J., Kwon, H.-Y., Im, S.H., Bae, M.A., Ahn, J.H., Lim, C.S., Teo, K.K.A., Park, S.Y., Kim, S.E., Lee, B.C., Lee, D.Y., and Chang, Y.-T. (2020). Multimodal imaging probe development for pancreatic β-cells: from fluorescence to PET. J Am Chem Soc. 142, 3430-3439. Feb 10

Dirice, E., De Jesus, D.F., Kahraman, S., Basile, G., Ng, R.W.S., El Ouaamari, A., Teo, K.K.A., Bhatt, S., Hu, J., and Kulkarni, R.N. (2019). Human duct cells contribute to β-cell compensation in insulin resistance. JCI Insight 4, 1-14. May 6

Dirice, E., Kahraman, S., De Jesus, D.F., El Ouaamari, A., Basile, G., Baker, R., Yigit, B., Piehowski, P.D., Kim, M.J., Dwyer, A.J., Ng, R.W.S., Schuser, C., Vethe, H., Martinov, T., Ishikawa, Y., Teo, K.K.A., Smith, R.D., Hu, J., Haskins, K., Serwold, T., Qian, W.-J., Fife, B.T., Kissler, S., and Kulkarni, R.N. (2019). Increased β-cell proliferation prior to immune-cell invasion prevents progression of type 1 diabetes. Nat Metab 1, 509-518. Apr 18

Isaac, A.*, Kodali, A.*, Nguyen, L., Teo, K.K.A., Chang, C.W., Karnani, N., Ng, K.L., Chong, Y.S., Gluckman, P.D., and Stunkel, W. (2017). Gestational diabetes alters functions in offspring's umbilical cord cells with implications for cardiovascular health. Endocrinology 158, 2102-2112. Jul 1
Selected for Endocrine Society Thematic Issue: Diabetes 2018
(https://academic.oup.com/endocrinesociety/pages/thematic_issue_diabetes_2018)

PUBLICATIONS BASED ON POSTDOCTORAL RESEARCH

Gupta, M.K., Teo, K.K.A., Rao, T.N., Bhatt, S., Kleinridders, A., Shirakawa, J., Takatani, T., Hu, J., De Jesus, D.F., Windmueller, R., Wagers, A.J., and Kulkarni, R.N. (2015). Excessive cellular proliferation negatively impacts reprogramming efficiency of human fibroblasts. Stem Cells Transl Med 4, 1101-1108. Aug 7

Teo, K.K.A.*, Gupta, M.K., Doria, A., and Kulkarni, R.N.* (2015). Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools. Mol Metab 4, 593-604. Jun 20 *Corresponding authors

Teo, K.K.A., Tsuneyoshi, N., Hoon, S., Tan, E.-K., Stanton, L.W., Wright, C.V., and Dunn, N.R. (2015). PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells. Stem Cell Reports 4, 578-590. Apr 2
Featured in https://research.a-star.edu.sg/wp-content/uploads/2019/04/12-ASTAR_RESEARCH_0915.pdf

Valdez, I.A.#, Teo, K.K.A.#*, and Kulkarni, R.N.* (2015). Cellular stress drives pancreatic plasticity. Sci. Transl. Med. 7, 273ps2. Feb 4 #First authors *Corresponding authors

Teo, K.K.A.*, Valdez, I.A., Dirice, E., and Kulkarni, R.N.* (2014). Comparable generation of Activin-induced definitive endoderm via additive Wnt or BMP signalling in absence of serum. Stem Cell Reports 3, 5-14. Jul 8 *Corresponding authors

Dirice, E., Kahraman, S., Jiang, W., El Ouaamari, A., De Jesus, D., Teo, K.K.A., Hu, J., Kawamori, D., Gaglia, J., Mathis, D., and Kulkarni, R.N. (2014). Soluble factors secreted by T-cells promote β cell proliferation. Diabetes 63, 188-202. Jan

Teo, K.K.A., Wagers, A.J., and Kulkarni, R.N. (2013). New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metabolism 18, 775-791. Sep 12

Teo, K.K.A., Windmueller, R., Johansson, B.B., Dirice, E., Njolstad, P.R., Tjora, E., Raeder, H., and Kulkarni, R.N. (2013). Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem. 288, 5353-5356. Jan 10

Teo, K.K.A., and Kulkarni, R.N. (2012). Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. EMBO J. 31, 3956-3957. Sep 14

Teo, K.K.A.*, Ali, Y.*, Wong, K.Y., Chipperfield, H., Sadasivam, A., Poobalan, Y., Tan, E.-K., Wang, S.-T., Abraham, S., Tsuneyoshi, N., Stanton, L.W., and Dunn, N.R. (2012). Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells. Stem Cells 30, 631-642. Apr *First authors

PUBLICATIONS BASED ON PHD RESEARCH

Brown, S., Teo, A., Pauklin, S., Hannan, N., Cho, C.H.-H., Lim, B., Vardy, L., Dunn, N.R., Trotter, M.W.B., Pedersen, R., and Vallier, L. (2011). Activin/Nodal signalling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells 29, 1176-1185. Aug

Teo, K.K.A., Arnold, S.J., Trotter, M.W.B., Brown, S., Ang, L.T., Chng, Z., Robertson, E.J., Dunn, N.R., and Vallier, L. (2011). Pluripotency factors regulate definitive endoderm specification through Eomesodermin. Genes Dev. 25, 238-250. Jan 18

Perspective: Loh, K.M., and Lim, B. (2011). A precarious balance: pluripotency factors as lineage specifiers.
F1000Prime article recommendation: http://f1000.com/prime/8271956

Teo, K.K.A., and Vallier, L. (2010). Emerging use of stem cells in regenerative medicine. Biochem. J. 428, 11-23. Apr 28

Chng, Z., Teo, A., Pedersen, R.A., and Vallier, L. (2010). SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell 6, 59-70. Jan 8

Vallier, L., Mendjan, S., Brown, S., Chng, Z., Teo, A., Smithers, L.E., Trotter, M.W., Cho, C.H., Martinez, A., Rugg-Gunn, P., Brons, G., and Pedersen, R.A. (2009). Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development 136, 1339-1349. Mar 11