Adrian Teo Laboratory


Ng, H.J.N., Tan, W.X., Koh, Y.X., and Teo, K.K.A. (2019). Human islet isolation and distribution efforts for clinical and basic research. OBM transplantation 3, 1-31.

Ng, H.J.N.#, Jasmen, B.J.#, Lim, C.S., Lau, H.H., Krishnan, V.G., Kadiwala, J., Kulkarni, R.N., Raeder, H., Vallier, L., Hoon, S., and Teo, K.K.A. (2019). HNF4A haploinsufficiency in MODY1 abrogates liver and pancreas differentiation from patient-derived iPSCs. iScience 16, 192-205.
#First authors

Kang, N.-Y.#*, Soetedjo, A.A.P.#, Amirruddin, N.S., Chang, Y.-T., Eriksson, O., and Teo, K.K.A.* (2019). Tools for bioimaging pancreatic beta cells in diabetes. Trends Mol Med 25, 708-722.
#First authors
*Corresponding authors

     Featured Article

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Dirice, E., De Jesus, D.F., Kahraman, S., Basile, G., Ng, R.W.S., El Ouaamari, A., Teo, K.K.A., Bhatt, S., Hu, J., and Kulkarni, R.N. (2019). Human duct cells contribute to β-cell compensation in insulin resistance. JCI Insight 4, 1-14.

Dirice, E., Kahraman, S., De Jesus, D.F., El Ouaamari, A., Basile, G., Baker, R., Yigit, B., Piehowski, P.D., Kim, M.J., Dwyer, A.J., Ng, R.W.S., Schuser, C., Vethe, H., Martinov, T., Ishikawa, Y., Teo, K.K.A., Smith, R.D., Hu, J., Haskins, K., Serwold, T., Qian, W.-J., Fife, B.T., Kissler, S., and Kulkarni, R.N. (2019). Increased β-cell proliferation prior to immune-cell invasion prevents progression of type 1 diabetes. Nat Metab 1, 509-518.

Nguyen, L., Chan, S.Y., and Teo, K.K.A. (2018). Metformin from mother to unborn child – are there unwarranted effects? EBioMedicine 35, 394-404.

​​​​Ng, H.J.N., and Teo, K.K.A. (2018). Heterogeneity and cell fate flux in single human pancreatic islet cells. Cell Death Disease 9, 222.

Teo, K.K.A.*, Lim, C.S., Cheow, L.F., Kin, T., Shapiro, J.A., Kang, N.-Y., Burkholder, W., and Lau, H.H. (2018). Single cell analyses of human islet cells reveal de-differentiation signatures. Cell Death Discovery 4, 14. 

*Corresponding author

Lau, H.H., Ng, H.J.N., Loo, S.W.L., Jasmen, B.J., and Teo, K.K.A. (2018). The molecular functions of hepatocyte nuclear factors – in and beyond the liver. J Hepatol. 68, 1033-1048.

Loo, S.W.L., Lau, H.H., Jasmen, B.J., Lim, C.S., and Teo, K.K.A. (2018). An arduous journey from human pluripotent stem cells to functional pancreatic β-cells. Diabetes, Obesity and Metabolism 20, 3-13.

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Isaac, A.*, Kodali, A.*, Nguyen, L., Teo, K.K.A., Chang, C.W., Karnani, N., Ng, K.L., Chong, Y.S., Gluckman, P.D., and Stunkel, W. (2017). Gestational diabetes alters functions in offspring's umbilical cord cells with implications for cardiovascular health. Endocrinology 158, 2102-2112.

​Valdez, I.A., Dirice, E., Gupta, M.K., Shirakawa, J., Teo, K.K.A.*, and Kulkarni, R.N.* (2016) Proinflammatory cytokines induce endocrine differentiation in pancreatic ductal cells via STAT3-dependent NGN3 activation. Cell Reports 15, 1-11.
*Co-senior and Co-corresponding authors

Teo, K.K.A.*, Lau, H.H., Valdez, I.A., Dirice, E., Tjora, E., Raeder, H., and Kulkarni, R.N.* (2016). Early developmental perturbations in a human stem cell model of MODY5/HNF1B pancreatic hypoplasia. Stem Cell Reports 6, 357-367.
*Corresponding authors

Santosa, M., Low S.J.B., Pek M.Q.N., and Teo, K.K.A. (2016). Knowledge gaps in rodent pancreas biology: taking human pluripotent stem cell-derived pancreatic beta cells into our own hands. Front. Endocrinol. 6, 194.

Gupta, M.K., Teo, K.K.A., Rao, T.N., Bhatt, S., Kleinridders, A., Shirakawa, J., Takatani, T., Hu, J., De Jesus, D.F., Windmueller, R., Wagers, A.J., and Kulkarni, R.N. (2015). Excessive cellular proliferation negatively impacts reprogramming efficiency of human fibroblasts. Stem Cells Transl Med 4, 1101-1108.

Teo, K.K.A.*, Gupta, M.K., Doria, A., and Kulkarni, R.N.* (2015). Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools. Mol Metab 4, 593-604.
*Corresponding authors

Teo, K.K.A., Tsuneyoshi, N., Hoon, S., Tan, E.-K., Stanton, L.W., Wright, C.V., and Dunn, N.R. (2015). PDX1 binds and represses hepatic genes to ensure robust pancreatic commitment in differentiating human embryonic stem cells. Stem Cell Reports 4, 578-590.

Valdez, I.A.#, Teo, K.K.A.#*, and Kulkarni, R.N.* (2015). Cellular stress drives pancreatic plasticity. Sci. Transl. Med. 7, 273ps2.
#First authors
*Corresponding authors

Teo, K.K.A.*, Valdez, I.A., Dirice, E., and Kulkarni, R.N.* (2014). Comparable generation of Activin-induced definitive endoderm via additive Wnt or BMP signalling in absence of serum. Stem Cell Reports 3, 5-14.
*Corresponding authors

Dirice, E., Kahraman, S., Jiang, W., El Ouaamari, A., De Jesus, D., Teo, K.K.A., Hu, J., Kawamori, D., Gaglia, J., Mathis, D., and Kulkarni, R.N. (2014). Soluble factors secreted by T-cells promote β cell proliferation. Diabetes 63, 188-202. 

Teo, K.K.A., Wagers, A.J., and Kulkarni, R.N. (2013). New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metabolism 18, 775-791. 

Teo, K.K.A., Windmueller, R., Johansson, B.B., Dirice, E., Njolstad, P.R., Tjora, E., Raeder, H., and Kulkarni, R.N. (2013). Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem. 288, 5353-5356.  ​

Teo, K.K.A., and Kulkarni, R.N. (2012). Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. EMBO J. 31, 3956-3957.  ​

Teo, K.K.A.*, Ali, Y.*, Wong, K.Y., Chipperfield, H., Sadasivam, A., Poobalan, Y., Tan, E.-K., Wang, S.-T., Abraham, S., Tsuneyoshi, N., Stanton, L.W., and Dunn, N.R. (2012). Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells. Stem Cells 30, 631-642.

*Equal contribution 

​Brown, S., Teo, A., Pauklin, S., Hannan, N., Cho, C.H.-H., Lim, B., Vardy, L., Dunn, N.R., Trotter, M.W.B., Pedersen, R., and Vallier, L. (2011). Activin/Nodal signalling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells 29, 1176-1185.  ​

Teo, K.K.A., Arnold, S.J., Trotter, M.W.B., Brown, S., Ang, L.T., Chng, Z., Robertson, E.J., Dunn, N.R., and Vallier, L. (2011). Pluripotency factors regulate definitive endoderm specification through Eomesodermin. Genes Dev. 25, 238-250.  ​

     Perspective: Loh, K.M., and Lim, B. (2011). A precarious balance: pluripotency factors as lineage specifiers. 

     Faculty of 1000: 2011. 

Teo, K.K.A., and Vallier, L. (2010). Emerging use of stem cells in regenerative medicine. Biochem. J. 428, 11-23.  ​

Chng, Z., Teo, A., Pedersen, R.A., and Vallier, L. (2010). SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Cell Stem Cell 6, 59-70. 

Vallier, L., Mendjan, S., Brown, S., Chng, Z., Teo, A., Smithers, L.E., Trotter, M.W., Cho, C.H., Martinez, A., Rugg-Gunn, P., Brons, G., and Pedersen, R.A. (2009). Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development 136, 1339-1349.